Silver Sulfadiazine is formulated to be utilized along with other treatments in order to prevent & treat wound infections in patients with serious burns. It works by stopping the development of bacteria that may infect an open wound. Silver Sulfadiazine is commonly applied one time or two time in a day. Don't stop using this kind of medicine until your doctor tells you to do so. Your mark or area must be healed so that infection is no longer a problem.